Major genetic marker of nidoviruses encodes a replicative endoribonuclease
نویسندگان
چکیده
منابع مشابه
Major genetic marker of nidoviruses encodes a replicative endoribonuclease.
Coronaviruses are important pathogens that cause acute respiratory diseases in humans. Replication of the approximately 30-kb positive-strand RNA genome of coronaviruses and discontinuous synthesis of an extensive set of subgenome-length RNAs (transcription) are mediated by the replicase-transcriptase, a barely characterized protein complex that comprises several cellular proteins and up to 16 ...
متن کاملBiochemical characterization of arterivirus nonstructural protein 11 reveals the nidovirus-wide conservation of a replicative endoribonuclease.
Nidoviruses (arteriviruses, coronaviruses, and roniviruses) are a phylogenetically compact but diverse group of positive-strand RNA viruses that includes important human and animal pathogens. Nidovirus RNA synthesis is mediated by a cytoplasmic membrane-associated replication/transcription complex that includes up to 16 viral nonstructural proteins (nsps), which carry common enzymatic activitie...
متن کاملA Review of Microsatellite Marker Usage in the Assessment of Genetic Diversity of Camelus
Camels have been regarded as the desert ship and they play multi-utility role in the world. Estimation of genetic parameters is foremost step towards managing the genetic resources for their conservation and sustainable utilization. Microsatellite markers have been extensively used in cattle, sheep, goat and camels. However, genetic characterization studies on camels has been poorly recorded. T...
متن کاملA candidate prostate cancer susceptibility gene encodes tRNA 3' processing endoribonuclease.
tRNA 3' processing endoribonuclease (3' tRNase) is an enzyme responsible for the removal of a 3' trailer from precursor tRNA (pre-tRNA). We purified approximately 85 kDa 3' tRNase from pig liver and determined its partial sequences. BLAST search of them suggested that the enzyme was the product of a candidate human prostate cancer susceptibility gene, ELAC2, the biological function of which was...
متن کاملBiochemical and genetic analyses of murine hepatitis virus Nsp15 endoribonuclease.
The goal of this project was to better define the relationship between the endoribonuclease activity of murine hepatitis virus (MHV) Nsp15 (mNsp15) and its role in virus infection. Molecular modeling demonstrated that the catalytic residues of mNsp15 are superimposable with its severe acute respiratory syndrome coronavirus ortholog. Alanine substitutions at three key residues in the mNsp15 cata...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2004
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0403127101